Medicinal Chemistry

Preface to the First Edition xv

Preface to the Second Edition xvii

Acknowledgements xix

Abbreviations xxi

1 An introduction to drugs, their action and discovery 1

1.1 Introduction 1

1.2 What are drugs and why do we need new ones? 1

1.3 Drug discovery and design: a historical outline 3

1.3.1 The general stages in modern-day drug discovery and design 7

1.4 Leads and analogues: some desirable propert...