The role of BACE1 in Alzheimer's disease and its suitability as a therapeutic target

Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by cognitive impairment, loss of neuronal cells and synaptic connections. The main pathological feature of the disease is the β amyloid peptide, generated by the cleavage of the Amyloid Precursor Protein by the β-secretase enzyme (Beta-site APP-cleaving enzyme 1 (BACE1)). There have been many factors involved in the ...