PART I.—INTRODUCTORY. | ||
I. THE OLD POISON-LORE. | ||
Section | Page | |
1. | The History of the Poison-lehre—The Origin of Arrow-Poison—Greek Myths, | 1 |
2. | Knowledge of the Egyptians relative to Poisons—Distillation of Peach-Water, | 2 |
3. | Roman and Greek Knowledge of Poison—Sanction of Suicide among the Ancients—The Classification of Poisons adopted by Dioscorides, | 2-4 |
4. | Poisoning among Eastern Nations—Slow Poisons, | 4, 5 |
5. | Hebrew Knowledge of Poisons, | 5 |
6. | The part which Poison has played in History—Statira—Locusta—Britannicus—The Rise of Anatomy—The Death of Alexander the Great—of Pope Alexander VI.—The Commission of Murder given by Charles le Mauvais—Royal Poisoners—Charles IX.—King John—A Female Poisoner boiled alive, | 5-9 |
7. | The Seventeenth Century Italian Schools of Criminal Poisoning—The Council of Ten—John of Ragubo—The Professional Poisoner—J. B. Porta’s Treatise on Natural Magic—Toffana and the “Acquetta di Napoli”—Organic Arsenical Compounds—St. Croix and Madame de Brinvilliers—Extraordinary Precautions for the Preservation from Poison of the Infant Son of Henry VIII., | 9-13 |
II. GROWTH AND DEVELOPMENT OF THE MODERN METHODS OF CHEMICALLY DETECTING POISONS. | ||
8. | Phases through which the Art of Detecting Poisons has passed, | 13 |
9. | Treatise of Barthélémy d’Anglais—Hon. Robert Boyle—Nicolas l’Emery’s Cours de Chimie—Mead’s Mechanical Theory of Poisons—Rise of Modern Chemistry—Scheele’s Discoveries, | 13, 14 |
10. | History of Marsh’s Test, | 14, 15 |
11. | Orfila and his Traité de Toxicologie—Orfila’s Method of Experiment, | 15 |
12. | The Discovery of the Alkaloids—Separation of Narcotine, Morphine, Strychnine, Delphinine, Coniine, Codeine, Atropine, Aconitine, and Hyoscyamine, | 15, 16 |
13. | Bibliography of the Chief Works on Toxicology of the Nineteenth Century, | 16-19 |
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PART II. | ||
I. DEFINITION OF POISON. | ||
14. | The Legal Definition of Poison—English Law as to Poison, | 20, 21 |
15. | German Law as to Poisoning—French Law as to Poisoning, | 21, 22 |
16. | Scientific Definition of a Poison—The Author’s Definition, | 22, 23 |
II. CLASSIFICATION OF POISONS. | ||
17. | Foderé’s, Orfila’s, Casper’s, Taylor’s, and Guy’s Definition of Poisons—Poisons arranged according to their Prominent Effects, | 23, 24 |
18. | Kobert’s Classification, | 24, 25 |
19. | The Author’s Arrangement, | 25-28 |
III. STATISTICS. | ||
20. | Statistics of Poisoning in England and Wales during the Ten Years 1883-92—Various Tables, | 28-31 |
21. | German Statistics of Poisoning, | 31-33 |
22. | Criminal Poisoning in France, | 33, 34 |
IV. THE CONNECTION BETWEEN TOXIC ACTION AND CHEMICAL COMPOSITION. | ||
23. | The Influence of Hydroxyl—The Replacement of Hydrogen by a Halogen—Bamberger’s Acylic and Aromatic Bases, | 35, 36 |
24. | The Replacement of Hydrogen by Alkyls in Aromatic Bodies, | 36-38 |
25. | The Influence of Carbonyl Groups, | 39 |
26. | Oscar Loew’s Theory as to the Action of Poisons, | 39-41 |
27. | Michet’s Experiments on the relative Toxicity of Metals, | 41, 42 |
V. LIFE TESTS: OR THE IDENTIFICATION OF POISON BY EXPERIMENTS ON ANIMALS. | ||
28. | The Action of Poisons on Infusoria, Cephalopoda, Insects, | 42-44 |
29. | Effect of Poisons on the Heart of Cold-blooded Animals, | 44, 45 |
30. | The Effect of Poisons on the Iris, | 45, 46 |
VI. GENERAL METHOD OF PROCEDURE IN SEARCHING FOR POISON. | ||
31. | Concentration in a Vacuum—Drying the Substance—Solvents—Destruction of Organic Matter, | 46-50 |
32. | Autenrieth’s General Process—Distillation—Shaking up with Solvents—Isolation of Metals—Investigation of Sulphides Soluble in Ammonium Sulphide—of Sulphides Insoluble in Ammonium Sulphide—Search for Zinc and Chromium—Search for Lead, Silver, and Barium, | 50-53 |
VII. THE SPECTROSCOPE AS AN AID TO THE IDENTIFICATION OF CERTAIN POISONS. | ||
33. | The Micro-Spectroscope—Oscar Brasch’s Researches of the Spectra of Colour Reactions—Wave Lengths, | 54-56 |
Examination of Blood or of Blood-Stains. | ||
34. | Naked-eye Appearance of Blood-Stains—Dragendorff’s Process for Dissolving Blood, | 56, 57 |
35. | Spectroscopic Appearances of Blood—Spectrum of Hydric Sulphide Blood—of Carbon Oxide Hæmoglobin—Methæmoglobin—of Acid Hæmatin—Tests for CO Blood—Piotrowski’s Experiments on CO Blood—Preparation of Hæmatin Crystals—The Guaiacum Test for Blood, | 57-62 |
36. | Distinction between the Blood of Animals and Men—The Alkalies in various Species of Blood, | 62, 63 |
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PART III.—POISONOUS GASES: CARBON MONOXIDE—CHLORINE—HYDRIC SULPHIDE. | ||
I. CARBON MONOXIDE. | ||
37. | Properties of Carbon Monoxide, | 64 |
38. | Symptoms—Acute Form—Chronic Form, | 64-66 |
39. | Poisonous Action on the Blood—Action on the Nervous System, | 66, 67 |
40. | Post-mortem Appearances, | 67 |
41. | Mass Poisonings by Carbon Monoxide—The Leeds Case—The Darlaston Cases, | 67-70 |
42. | Detection of Carbon Monoxide—The Cuprous Chloride Method—Wanklyn’s Method—Hempel’s Method, | 70, 71 |
II. CHLORINE. | ||
43. | Chlorine; its Properties—The Weldon Process of manufacturing “Bleaching Powder,” | 71, 72 |
44. | Effects of Chlorine, | 72 |
45. | Post-mortem Appearances, | 72 |
46. | Detection of Free Chlorine, | 72 |
III. HYDRIC SULPHIDE (SULPHURETTED HYDROGEN). | ||
47. | Properties of Hydric Sulphide, | 72, 73 |
48. | Effects of breathing Hydric Sulphide—Action on the Blood—The Cleator Moor Case, | 73, 74 |
49. | Post-mortem Appearances, | 74 |
50. | Detection, | 74 |
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PART IV.—ACIDS AND ALKALIES. | ||
Sulphuric Acid—Hydrochloric Acid—Nitric Acid—Acetic Acid—Ammonia—Potash—Soda—Neutral Sodium, Potassium, and Ammonium Salts. | ||
I. SULPHURIC ACID. | ||
51. | Varieties and Strength of the Sulphuric Acids of Commerce—Properties of the Acid—Nordhausen Sulphuric Acid, | 75, 76 |
52. | Properties of Sulphuric Anhydride, | 76 |
53. | Occurrence of Free Sulphuric Acid in Nature, | 76 |
54. | Statistics—Comparative Statistics of different Countries, | 76, 77 |
55. | Accidental, Suicidal, and Criminal Poisoning—Sulphuric Acid in Clysters and Injections, | 77, 78 |
56. | Fatal Dose, | 78, 79 |
57. | Local Action of Sulphuric Acid—Effects on Mucous Membrane, on the Skin, on Blood, | 79, 80 |
58. | Action of Sulphuric Acid on Earth, Grass, Wood, Paper, Carpet, Clothing, Iron—Caution necessary in judging of Spots—Illustrative Case, | 80, 81 |
59. | Symptoms—(1) External Effects—(2) Internal Effects in the Gullet and Stomach—Intercostal Neuralgia, | 81-83 |
60. | Treatment of Acute Poisoning by the Mineral Acids, | 83 |
61. | Post-mortem Appearances—Rapid and Slow Poisoning—Illustrative Cases, | 83-85 |
62. | Pathological Preparations in the different London Hospital Museums, | 85, 86 |
63. | Chronic Poisoning, | 86 |
Detection and Estimation of Free Sulphuric Acid. | ||
64. | General Method of Separating the Free Mineral Acids—The Quinine Process—The Old Process of Extraction by Alcohol—Hilger’s Test for Mineral Acid, | 87, 88 |
65. | The Urine—Excretion of Sulphates in Health and Disease—The Characters of the Urine after taking Sulphuric Acid, | 88-90 |
66. | The Blood in Sulphuric Acid Poisoning, | 90 |
67. | The Question of the Introduction of Sulphates by the Food—Largest possible Amount of Sulphates introduced by this Means—Sulphur of the Bile—Medicinal Sulphates, | 90, 91 |
II. HYDROCHLORIC ACID. | ||
68. | General Properties of Hydrochloric Acid—Discovery—Uses—Tests, | 91, 92 |
69. | Statistics, | 92, 93 |
70. | Fatal Dose, | 93 |
71. | Amount of Free Acid in the Gastric Juice, | 93, 94 |
72. | Influence of Hydrochloric Acid on Vegetation—Present Law on the Subject of Acid Emanations from Works—The Resistant Powers of various Plants, | 94 |
73. | Action on Cloth and Manufactured Articles, | 95 |
74. | Poisonous Effects of Hydrochloric Acid Gas—Eulenberg’s Experiments on Rabbits and Pigeons, | 95, 96 |
75. | Effects of the Liquid Acid—Absence of Corrosion of the Skin—Pathological Appearances—Illustrative Cases, | 96, 97 |
76. | Post-mortem Appearances—Preparations in the different London Museums, | 97, 98 |
77. | (1) Detection of Free Hydrochloric Acid—Günzburg’s Test—A. Villiers’s and M. Favolle’s Test—(2) Quantitative Estimation, Sjokvist’s Method—Braun’s Method, | 98-101 |
78. | Method of Investigating Hydrochloric Acid Stains on Cloth, &c., | 101, 102 |
III. NITRIC ACID. | ||
79. | Properties of Nitric Acid, | 102, 103 |
80. | Use in the Arts, | 103 |
81. | Statistics, | 103 |
82. | Fatal Dose, | 104 |
83. | Action on Vegetation, | 104 |
84. | Effects of Nitric Acid Vapour—Experiments of Eulenberg and O. Lassar—Fatal Effect on Man, | 104, 105 |
85. | Effects of Liquid Nitric Acid—Suicidal, Homicidal, and Accidental Deaths from the Acid, | 105, 106 |
86. | Local Action, | 106 |
87. | Symptoms—The Constant Development of Gas—Illustrative Cases, | 106, 107 |
88. | Post-mortem Appearances—Preparations in various Anatomical Museums, | 107-109 |
89. | Detection and Estimation of Nitric Acid, | 109, 110 |
IV. ACETIC ACID. | ||
90. | Symptoms and Detection, | 110 |
V. AMMONIA. | ||
91. | Properties of Ammonia, | 111 |
92. | Uses—Officinal and other Preparations, | 111, 112 |
93. | Statistics of Poisoning by Ammonia, | 112 |
94. | Poisoning by Ammonia Vapour, | 112 |
95. | Symptoms—Illustrative Case, | 112, 113 |
96. | Chronic Effects of the Gas, | 113 |
97. | Ammonia in Solution—Action on Plants, | 113 |
98. | Action on Human Beings and Animal Life—Local Action on Skin—Action on the Blood—Time of Death, | 113-115 |
99. | Post-mortem Appearances, | 115 |
100. | Separation of Ammonia—Tests, | 115, 116 |
101. | Estimation of Ammonia, | 116 |
VI. CAUSTIC POTASH AND SODA. | ||
102. | Properties of Potassium Hydrate, | 116, 117 |
103. | Pharmaceutical Preparations, | 117 |
104. | Carbonate of Potash, | 117 |
105. | Bicarbonate of Potash, | 117 |
106. | Caustic Soda—Sodium Hydrate, | 117, 118 |
107. | Carbonate of Soda, | 118 |
108. | Bicarbonate of Soda, | 118 |
109. | Statistics, | 118 |
110. | Effects on Animal and Vegetable Life, | 118, 119 |
111. | Local Effects, | 119 |
112. | Symptoms, | 119 |
113. | Post-mortem Appearances, | 119-121 |
114. | Chemical Analysis, | 121 |
115. | Estimation of the Fixed Alkalies, | 121, 122 |
VII. NEUTRAL SODIUM, POTASSIUM, AND AMMONIUM SALTS. | ||
116. | Relative Toxicity of Sodium, Potassium, and Ammonium Salts, | 122 |
117. | Sodium Salts, | 122 |
118. | Potassium Salts—Potassic Sulphate—Hydropotassic Tartrate—Statistics, | 122 |
119. | Action on the Frog’s Heart, | 122 |
120. | Action on Warm-Blooded Animals, | 122, 123 |
121. | Elimination, | 123 |
122. | Nitrate of Potash, | 123 |
123. | Statistics, | 123 |
124. | Uses in the Arts, | 123 |
125. | Action of Nitrates of Sodium and Potassium—Sodic Nitrite, | 123, 124 |
126. | Post-mortem Appearances from Poisoning by Potassic Nitrate, | 124 |
127. | Potassic Chlorate, | 124 |
128. | Uses, | 124 |
129. | Poisonous Properties, | 124 |
130. | Experiments on Animals, | 124, 125 |
131. | Effects on Man—Illustrative Cases of the Poisoning of Children by Potassic Chlorate, | 125 |
132. | Effects on Adults—Least Fatal Dose, | 126 |
133. | Elimination, | 126 |
134. | Essential Action of Potassic Chlorate on the Blood and Tissues, | 126 |
135. | Detection and Estimation of Potassic Chlorate, | 126, 127 |
Toxicological Detection of Alkali Salts. | ||
136. | Natural occurrence of Potassium and Sodium Salts in the Blood and Tissues—Tests for Potassic and Sodic Salts—Tests for Potassic Nitrate—Tests for Chlorates—Ammonium Salts, | 127, 128 |
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PART V.—MORE OR LESS VOLATILE POISONOUS SUBSTANCES CAPABLE OF BEING SEPARATED BY DISTILLATION FROM NEUTRAL OR ACID LIQUIDS. | ||
Hydrocarbons—Camphor—Alcohol—Amyl Nitrite—Ether—Chloroform and other Anæsthetics—Chloral—Carbon Bisulphide—Carbolic Acid—Nitro-Benzene—Prussic Acid—Phosphorus. | ||
I. HYDROCARBONS. | ||
1. Petroleum. | ||
137. | Petroleum, | 129 |
138. | Cymogene, | 129 |
139. | Rhigolene, | 129 |
140. | Gasolene, | 129 |
141. | Benzoline—Distinction between Petroleum-Naphtha, Shale-Naphtha, and Coal-Tar Naphtha, | 129, 130 |
142. | Paraffin Oil, | 130 |
143. | Effects of Petroleum—Experiments on Rabbits, &c., | 130, 131 |
144. | Poisoning by Petroleum—Illustrative Cases, | 131 |
145. | Separation and Tests for Petroleum, | 131 |
2. Coal-Tar Naphtha—Benzene. | ||
146. | Composition of Commercial Coal-Tar Naphtha, | 131 |
147. | Symptoms observed after Swallowing Coal-Tar Naphtha, | 132 |
148. | Effects of the Vapour of Benzene, | 132 |
Detection and Separation of Benzene. | ||
149. | Separation of Benzene—(1) Purification; (2) Conversion into Nitro-Benzene; (3) Conversion into Aniline, | 132, 133 |
3. | Terpenes—Essential Oils—Oil of Turpentine. | |
150. | Properties of the Terpenes, Cedrenes, and Colophenes, | 133 |
4. Oil of Turpentine—Spirits of Turpentine. | ||
151. | Terebenthene—Distinction between French and English Turpentine, | 133, 134 |
152. | Effects of the Administration of Turpentine, | 134 |
II. CAMPHOR. | ||
153. | Properties of Camphor, | 135 |
154. | Pharmaceutical Preparations, | 135 |
155. | Symptoms of Poisoning by Camphor, | 135 |
156. | Post-mortem Appearances, | 136 |
157. | Separation from the Contents of the Stomach, | 136 |
III. ALCOHOLS. | ||
1. Ethylic Alcohol. | ||
158. | Chemical Properties of Alcohol—Statistics of Poisoning by Alcohol, | 136 |
159. | Criminal or Accidental Alcoholic Poisoning, | 137 |
160. | Fatal Dose, | 137 |
161. | Symptoms of Acute Poisoning by Alcohol, | 137, 138 |
162. | Post-mortem Appearances, | 138, 139 |
163. | Excretion of Alcohol, | 139, 140 |
164. | Toxicological Detection, | 140 |
2. Amylic Alcohol. | ||
165. | Properties of Amylic Alcohol, | 140 |
166. | Experiments as to the Effect on Animals of Amylic Alcohol, | 140, 141 |
167. | Detection and Estimation of Amylic Alcohol, | 141 |
168. | Amyl Nitrite—Properties—Symptoms—Post-mortem Appearances, | 141 |
IV. ETHER. | ||
169. | Properties of Ethylic Ether, | 141, 142 |
170. | Ether as a Poison, | 142 |
171. | Fatal Dose, | 142 |
172. | Ether as an Anæsthetic, | 142, 143 |
173. | Separation of Ether from Organic Fluids, &c., | 143 |
V. CHLOROFORM. | ||
174. | Discovery of Chloroform—Properties, Adulterations, and Methods for Detecting them, | 143-145 |
175. | Methods of Manufacturing Chloroform, | 145, 146 |
Poisonous Effects of Chloroform. | ||
1. As a Liquid. | ||
176. | Statistics, | 146 |
177. | Local Action, | 146 |
178. | Action on Blood, Muscle, and Nerve-Tissue, | 146 |
179. | General Effects of Liquid Chloroform—Illustrative Cases, | 146, 147 |
180. | Fatal Dose, | 147 |
181. | Symptoms, | 148 |
182. | Post-mortem Appearances, | 148 |
2. The Vapour of Chloroform. | ||
183. | Statistics of Deaths through Chloroform—Anæsthesia, | 148, 149 |
184. | Suicidal and Criminal Poisoning—Illustrative Cases, | 149, 150 |
185. | Physiological Effects, | 150 |
186. | Symptoms witnessed in Death from Chloroform Vapour, | 150, 151 |
187. | Chronic Chloroform Poisoning—Mental Effects from Use of Chloroform, | 151, 152 |
188. | Post-mortem Appearances, | 152 |
189. | The Detection and Estimation of Chloroform—Various Tests, | 152, 153 |
190. | Quantitative Estimation, | 153 |
VI. OTHER ANÆSTHETICS. | ||
191. | Methyl Chloride—Methene Dichloride, &c., | 154 |
192. | Pentane, | 154 |
193. | Aldehyde, | 154 |
194. | Paraldehyde, | 154 |
VII. CHLORAL. | ||
195. | Chloral Hydrate; its Composition and Properties, | 154, 155 |
196. | Detection, | 155 |
197. | Quantitative Estimation of Chloral Hydrate, | 155, 156 |
198. | Effects of Chloral Hydrate on Animals—Depression of Temperature—Influence on the Secretion of Milk, &c., | 156, 157 |
199. | Action upon the Blood, | 157 |
200. | Effects on Man, | 157, 158 |
201. | Fatal Dose, | 158, 159 |
202. | Symptoms, | 159 |
203. | Action of Chloral upon the Brain, | 159 |
204. | Treatment of Acute Chloral Poisoning, | 160 |
205. | Chronic Poisoning by Chloral Hydrate, | 160, 161 |
206. | Manner in which Chloral is Decomposed in, and Excreted from, the Body, | 161, 162 |
207. | Separation from Organic Matters—Tests for Chloral, | 162, 163 |
VIII. BISULPHIDE OF CARBON. | ||
208. | Properties of Bisulphide of Carbon, | 163 |
209. | Poisoning by Bisulphide of Carbon, | 163 |
210. | Action on Animals, | 163, 164 |
211. | Chronic Poisoning by Bisulphide of Carbon—Effects on the Brain, &c., | 164, 165 |
212. | Post-mortem Appearances, | 165 |
213. | Separation and Detection of Carbon Bisulphide—Tests, | 165 |
214. | Xanthogenic Acid, | 165 |
215. | Potassic Xanthogenate, | 165 |
IX. THE TAR ACIDS—PHENOL—CRESOL. | ||
216. | Properties and Sources of Carbolic Acid, | 165, 166 |
217. | Different Forms of Carbolic Acid—Calvert’s Carbolic Acid Powder—Carbolic Acid Soaps, | 166, 167 |
218. | Uses of Carbolic Acid, | 167 |
219. | Statistics Relative to Poisoning by Carbolic Acid, | 167-169 |
220. | Fatal Dose, | 169 |
221. | Effects on Animals—Infusoria—Fish—Frogs, | 169, 170 |
222. | Effects on Warm-Blooded Animals, | 170 |
223. | Symptoms Produced in Man—External Application—Action on the Skin—Effects of the Vapour—Use of Carbolic Acid Lotions—Injections, &c.—Illustrative Cases, | 170-172 |
224. | Internal Administration—Illustrative Cases, | 173 |
225. | General Review of the Symptoms induced by Carbolic Acid, | 173, 174 |
226. | Changes Produced in the Urine by Carbolic Acid, | 174, 175 |
227. | The Action of Carbolic Acid considered Physiologically, | 175, 176 |
228. | Forms under which Carbolic Acid is Excreted, | 176 |
229. | Post-mortem Appearances, | 176, 177 |
Tests for Carbolic Acid. | ||
230. | (1) The Pine-Wood Test—(2) Ammonia and Hypochlorite Test—(3) Ferric Chloride—(4) Bromine, | 177, 178 |
231. | Quantitative Estimation of Carbolic Acid, | 178, 179 |
232. | Properties of Cresol, and Tests for Distinguishing Cresol and Carbolic Acid, | 179 |
233. | Properties of Creasote—Tests, | 179, 180 |
234. | Separation of Carbolic Acid from Organic Fluids or Tissues, | 180, 181 |
235. | Examination of the Urine for Phenol or Cresol, | 181 |
236. | Assay of Disinfectants, Carbolic Acid Powders—E. Waller’s Process—Koppeschaar’s Volumetric Method—Colorimetric Method of Estimation, | 181-183 |
237. | Carbolic Acid Powders, | 183 |
238. | Carbolic Acid Soaps, | 183 |
X. NITRO-BENZENE. | ||
239. | Properties and Varieties, | 183, 184 |
240. | Effects of Poisoning by Nitro-Benzene, | 184 |
241. | Illustrative Cases of Poisoning by Nitro-Benzene Vapour, | 184, 185 |
242. | Effects Produced by taking Liquid Nitro-Benzene, | 185, 186 |
243. | Fatal Dose, | 186, 187 |
244. | Pathological Appearances, | 187 |
245. | The Essential Action of Nitro-Benzene, | 187, 188 |
246. | Detection and Separation from the Animal Tissues, | 188 |
XI. DINITRO-BENZOL. | ||
247. | Properties of Ortho-, Meta-, and Para-Dinitro-Benzol, | 189 |
248. | Effects of Dinitro-Benzol, | 189, 190 |
249. | The Blood in Nitro-Benzol Poisoning, | 191 |
250. | Detection of Dinitro-Benzol, | 192 |
XII. HYDROCYANIC ACID. | ||
251. | Properties of Hydrocyanic Acid, | 192 |
252. | Medicinal Preparations of Prussic Acid—Various Strengths of the Commercial Acid, | 192, 193 |
253. | Poisoning by Prussic Acid—Uses in the Arts—Distribution in the Vegetable Kingdom, | 193-195 |
254. | Composition and Varieties of Amygdalin, | 195 |
255. | Statistics of Poisoning by Prussic Acid, | 195-197 |
256. | Accidental and Criminal Poisoning, | 197, 198 |
257. | Fatal Dose, | 198 |
258. | Action of Hydric and Potassic Cyanides on Living Organisms, | 198, 199 |
259. | Symptoms observed in Animals, | 199, 200 |
260. | Length of Interval between taking the Poison and Death in Animals, | 200, 201 |
261. | Symptoms in Man, | 201, 202 |
262. | Possible Acts after taking the Poison—Nunneley’s Experiments, | 202, 203 |
263. | Chronic Poisoning by Hydric Cyanide, | 203 |
264. | Post-mortem Appearances, | 203, 204 |
265. | Tests for Hydrocyanic Acid and Cyanide of Potassium—Schönbein’s Test—Kobert’s Test, | 204-206 |
266. | Separation of Hydric Cyanide or Potassic Cyanide from Organic Matters—N. Sokoloff’s Experiments, | 206-208 |
267. | How long after Death can Hydric or Potassic Cyanide be Detected? | 208, 209 |
268. | Estimation of Hydrocyanic Acid or Potassic Cyanide, | 209 |
269. | Case of Poisoning by Bitter Almonds, | 209, 210 |
Poisonous Cyanides other than Hydric and Potassic Cyanides. | ||
270. | General Action of the Alkaline Cyanides—Experiments with Ammonic Cyanide Vapour, | 210 |
271. | The Poisonous Action of several Metallic and Double Cyanides—The Effects of Mercuric and Silver Cyanides; of Potassic and Hydric Sulphocyanides; of Cyanogen Chloride; of Methyl Cyanide, and of Cyanuric Acid, | 210, 211 |
XIII. PHOSPHORUS. | ||
272. | Properties of Phosphorus—Solubility—Effects of Heat on Phosphorus, | 212, 213 |
273. | Phosphuretted Hydrogen—Phosphine, | 213 |
274. | The Medicinal Preparations of Phosphorus, | 213 |
275. | Matches and Vermin Paste, | 213-215 |
276. | Statistics of Phosphorus Poisoning, | 215, 216 |
277. | Fatal Dose, | 216 |
278. | Effects of Phosphorus, | 217 |
279. | Different Forms of Phosphorus Poisoning, | 217, 218 |
280. | Common Form, | 218, 219 |
281. | Hæmorrhagic Form, | 219 |
282. | Nervous Form, | 219 |
283. | Sequelæ, | 219, 220 |
284. | Period at which the First Symptoms commence, | 220 |
285. | Period of Death, | 220 |
286. | Effects of Phosphorus Vapour—Experiments on Rabbits, | 220, 221 |
287. | Effects of Chronic Phosphorus Poisoning, | 221, 222 |
288. | Changes in the Urinary Secretion, | 222 |
289. | Changes in the Blood, | 222, 223 |
290. | Antidote—Treatment by Turpentine, | 223 |
291. | Poisonous Effects of Phosphine, | 223, 224 |
292. | Coefficient of Solubility of Phosphine in Blood compared with Pure Water, | 224 |
293. | Post-mortem Appearances—Effects on the Liver, | 224-228 |
294. | Pathological Changes in the Kidneys, Lungs, and Nervous System, | 228 |
295. | Diagnostic Differences between Acute Yellow Atrophy of the Liver and Fatty Liver produced by Phosphorus, | 228, 229 |
296. | Detection of Phosphorus—Mitscherlich’s Process—The Production of Phosphine—Tests Dependent on the Combustion of Phosphine, | 229-232 |
297. | The Spectrum of Phosphine—Lipowitz’s Sulphur Test—Scherer’s Test, | 232, 233 |
298. | Chemical Examination of the Urine, | 233, 234 |
299. | Quantitative Estimation of Phosphorus, | 234 |
300. | How long can Phosphorus be recognised after Death? | 234, 235 |
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PART VI.—ALKALOIDS AND POISONOUS VEGETABLE PRINCIPLES SEPARATED FOR THE MOST PART BY ALCOHOLIC SOLVENTS. | ||
Division I.—Vegetable Alkaloids. | ||
I. GENERAL METHOD OF TESTING AND EXTRACTING ALKALOIDS. | ||
301. | General Tests for Alkaloids, | 236 |
302. | Group-Reagents, | 236, 237 |
303. | Phosphomolybdic, Silico-Tungstic, and Phospho-Tungstic Acids as Alkaloidal Reagents, | 237-239 |
304. | Schulze’s Reagent, | 239 |
305. | Dragendorff’s Reagent, | 239 |
306. | Colour Tests, | 239 |
307. | Stas’s Process, | 239 |
Methods of Separation. | ||
308. | Selmi’s Process for Separating Alkaloids, | 240, 241 |
309. | Dragendorff’s Process, | 241-254 |
310. | Shorter Process for Separating some of the Alkaloids, | 254, 255 |
311. | Scheibler’s Process for Alkaloids, | 255 |
312. | Grandval and Lajoux’s Method, | 255, 256 |
313. | Identification of the Alkaloids, | 256 |
314. | Sublimation of the Alkaloids, | 256-261 |
315. | Melting-point, | 261 |
316. | Identification by Organic Analysis, | 261, 262 |
317. | Quantitative Estimation of the Alkaloids—Mayer’s Reagent—Compound of the Alkaloids with Chlorides of Gold and Platinum, | 262-264 |
II. LIQUID VOLATILE ALKALOIDS. | ||
1. The Alkaloids of Hemlock (Conium). | ||
318. | Botanical Description of Hemlock, | 264 |
319. | Properties of Coniine—Tests, | 264-266 |
320. | Other Coniine Bases, | 266 |
321. | Pharmaceutical Preparations of Hemlock, | 266, 267 |
322. | Statistics of Coniine Poisoning, | 267 |
323. | Effects of Coniine on Animals, | 267, 268 |
324. | Effects of Coniine on Man, | 268 |
325. | Physiological Action of Coniine, | 268 |
326. | Post-mortem Appearances—Fatal Dose, | 268, 269 |
327. | Separation of Coniine from Organic Matters or Tissues, | 269 |
2. Tobacco—Nicotine. | ||
328. | General Composition of Tobacco, | 269, 270 |
329. | Quantitative Estimation of Nicotine in Tobacco, | 270, 271 |
330. | Nicotine; its Properties and Tests, | 271-273 |
331. | Effects of Nicotine on Animals, | 273, 274 |
332. | Effects of Nicotine on Man, | 274, 275 |
333. | Some Instances of Poisoning by Tobacco and Tobacco Juice, | 275-277 |
334. | Physiological Action of Nicotine, | 277, 278 |
335. | Fatal Dose, | 278 |
336. | Post-mortem Appearances, | 278 |
337. | Separation of Nicotine from Organic Matters, &c., | 278, 279 |
3. Piturie. | ||
338. | Properties of Piturie, | 279 |
4. Sparteine. | ||
339. | Properties of Sparteine, | 279, 280 |
5. Aniline. | ||
340. | Properties of Aniline, | 280 |
341. | Symptoms and Effects, | 280, 281 |
342. | Fatal Dose, | 281 |
343. | Detection of Aniline, | 281 |
III. THE OPIUM GROUP OF ALKALOIDS. | ||
344. | General Composition of Opium, | 281, 282 |
345. | Action of Solvents on Opium, | 282, 283 |
346. | The Methods of Teschemacher and Smith, of Dott and others for the Assay of Opium, | 283, 284 |
347. | Medicinal and other Preparations of Opium, | 284-288 |
348. | Statistics of Opiate Poisoning, | 288, 289 |
349. | Poisoning of Children by Opium, | 289 |
350. | Doses of Opium and Morphine—Fatal Dose, | 289, 290 |
351. | General Method for the Detection of Opium, | 290, 291 |
352. | Morphine; its Properties, | 291, 292 |
353. | Morphine Salts; their Solubility, | 292, 293 |
354. | Constitution of Morphine, | 293, 294 |
355. | Tests for Morphine and its Compounds—Production of Morphine Hydriodide—Iodic Acid Test and other Reactions—Transformation of Morphine into Codeine, | 294-296 |
356. | Symptoms of Opium and Morphine Poisoning—Action on Animals, | 296-298 |
357. | Physiological Action, | 298, 299 |
358. | Physiological Action of Morphine Derivatives, | 299 |
359. | Action on Man—(a) The Sudden Form; (b) the Convulsive Form; (c) a Remittent Form of Opium Poisoning—Illustrative Cases, | 299-303 |
360. | Diagnosis of Opium Poisoning, | 303, 304 |
361. | Opium-Eating, | 304-306 |
362. | Treatment of Opium or Morphine Poisoning, | 306 |
363. | Post-mortem Appearances, | 306, 307 |
364. | Separation of Morphine from Animal Tissues and Fluids, | 307 |
365. | Extraction of Morphine, | 308, 309 |
366. | Narcotine; its Properties and Tests, | 309, 310 |
367. | Effects of Narcotine, | 310 |
368. | Codeine—Properties of Codeine, | 310, 311 |
369. | Effects of Codeine on Animals—Claude Bernard’s Experiments, | 311 |
370. | Narceine—Properties of Narceine—Tests, | 312, 313 |
371. | Effects of Narceine, | 313, 314 |
372. | Papaverine—Properties of Papaverine—Tests, | 314 |
373. | Effects of Papaverine, | 314 |
374. | Thebaine; its Properties, | 314, 315 |
375. | Thebaine; its Effects, | 315 |
376. | Cryptopine, | 315, 316 |
377. | Rhœadine, | 316 |
378. | Pseudomorphine, | 316 |
379. | Opianine, | 316 |
380. | Apomorphine, | 316, 317 |
381. | Reactions of some of the Rarer Opium Alkaloids, | 317 |
382. | Tritopine, | 317 |
383. | Meconin (Opianyl), | 317 |
384. | Meconic Acid—Effects of Meconic Acid—Tests, | 318, 319 |
IV. THE STRYCHNINE OR TETANUS-PRODUCING GROUP OF ALKALOIDS. | ||
1. Nux Vomica Group—Strychnine—Brucine—Igasurine. | ||
385. | Nux Vomica—Characteristics of the Entire and of the Powdered Seed, | 319 |
386. | Chemical Composition of Nux Vomica, | 319 |
387. | Strychnine—Microscopical Appearances—Properties—Medicinal Preparations—Strychnine Salts, | 319-322 |
388. | Pharmaceutical and other Preparations of Nux Vomica, with Suggestions for their Valuation—Vermin-Killers, | 322-324 |
389. | Statistics, | 324-325 |
390. | Fatal Dose—Falck’s Experiments on Animals as to the Least Fatal Dose—Least Fatal Dose for Man, | 325-328 |
391. | Action on Animals—Frogs, | 328, 329 |
392. | Effects on Man—Symptoms—Distinction between “Disease Tetanus” and “Strychnos Tetanus,” | 329-331 |
393. | Diagnosis of Strychnine Poisoning, | 331, 332 |
394. | Physiological Action—Richet’s Experiments—The Rise of Temperature—Effect on the Blood-Pressure, | 332, 333 |
395. | Post-mortem Appearances, | 333 |
396. | Treatment, | 333 |
397. | Separation of Strychnine from Organic Matters—Separation from the Urine, Blood, and Tissues, | 334-337 |
398. | Identification of the Alkaloid—Colour Tests—Physiological Tests, | 337-339 |
399. | Hypaphorine, | 339 |
400. | Quantitative Estimation of Strychnine, | 339, 340 |
401. | Brucine; its Properties, | 340, 341 |
402. | Physiological Action of Brucine—Experiments of Falck, | 341, 342 |
403. | Tests for Brucine, | 342, 343 |
404. | Igasurine, | 344 |
405. | Strychnic Acid, | 344 |
2. The Quebracho Group of Alkaloids. | ||
406. | The Alkaloids of Quebracho—Aspidospermine—Quebrachine, | 344 |
3. Pereirine. | ||
407. | Pereirine, | 344, 345 |
4. Gelsemine. | ||
408. | Properties of Gelsemine, | 345 |
409. | Fatal Dose of Gelsemine, | 345 |
410. | Effects on Animals—Physiological Action, | 345 |
411. | Effects of Gelsemine on Man, | 346 |
412. | Extraction from Organic Matters, or the Tissues of the Body, | 347 |
5. Cocaine. | ||
413. | Cocaine; its Properties, | 47, 348 |
414. | Cocaine Hydrochlorate, | 348 |
415. | Pharmaceutical Preparations, | 348 |
416. | Separation of Cocaine and Tests, | 348, 349 |
417. | Symptoms, | 349 |
418. | Post-mortem Appearances, | 349, 350 |
419. | Fatal Dose, | 350 |
6. Corydaline. | ||
420. | Properties of Corydaline, | 350 |
V. THE ACONITE GROUP OF ALKALOIDS. | ||
421. | Varieties of Aconite—Description of the Flower, and of the Seeds, | 350, 351 |
422. | Pharmaceutical Preparations of Aconite, | 351 |
423. | The Aconite Alkaloids, | 351 |
424. | Aconitine, | 351, 352 |
425. | Tests for Aconitine, | 352 |
426. | Benzoyl-Aconine Properties—Recognition of Benzoic Acid, | 353, 354 |
427. | Pyraconitine, | 354 |
428. | Pyraconine, | 354 |
429. | Aconine, | 355 |
430. | Commercial Aconitine—English and German Samples of Aconitine—Lethal Dose of the Alkaloid and of the Pharmaceutical Preparations, | 355-358 |
431. | Effects of Aconitine on Animal Life—Insects, Fish, Reptiles, Birds, Mammals, | 358-360 |
432. | Statistics, | 361 |
433. | Effects on Man, | 361 |
434. | Poisoning by the Root (Reg. v. M’Conkey), | 361, 362 |
435. | Poisoning by the Alkaloid Aconitine—Three Cases of Poisoning, | 363, 364 |
436. | Lamson’s Case, | 364, 365 |
437. | Symptoms of Poisoning by the Tincture, &c., | 365, 366 |
438. | Physiological Action, | 366 |
439. | Post-mortem Appearances, | 366, 367 |
440. | Separation of Aconitine from the Contents of the Stomach or the Organs, | 367, 368 |
VI. THE MYDRIATIC GROUP OF ALKALOIDS—ATROPINE—HYOSCYAMINE—SOLANINE—CYTISINE. | ||
1. Atropine. | ||
441. | The Atropa belladonna; its Alkaloidal Content, | 368, 369 |
442. | The Datura stramonium—Distinction between Datura and Capsicum Seeds, | 369, 370 |
443. | Pharmaceutical Preparations—(a) Belladonna; (b) Stramonium, | 370, 371 |
444. | Properties of Atropine, | 371, 372 |
445. | Tests for Atropine, Chemical and Physiological, | 372-374 |
446. | Statistics of Atropine Poisoning, | 375 |
447. | Accidental and Criminal Poisoning by Atropine—Use of Dhatoora by the Hindoos, | 375, 376 |
448. | Fatal Dose of Atropine, | 376, 377 |
449. | Action on Animals, | 377 |
450. | Action on Man, | 377-380 |
451. | Physiological Action of Atropine, | 380 |
452. | Diagnosis of Atropine Poisoning, | 380 |
453. | Post-mortem Appearances, | 380 |
454. | Treatment of Cases of Poisoning by Atropine, | 380, 381 |
455. | Separation of Atropine from Organic Matters, &c., | 381 |
2. Hyoscyamine. | ||
456. | Distribution of Hyoscyamine—Properties, | 381-383 |
457. | Pharmaceutical and other Preparations of Henbane, | 383, 384 |
458. | Dose and Effects, | 384 |
459. | Separation of Hyoscyamine from Organic Matters, | 385 |
3. Hyoscine. | ||
460. | Hyoscine, | 385 |
4. Solanine. | ||
461. | Distribution of Solanine, | 385, 386 |
462. | Properties of Solanine, | 386 |
463. | Solanidine, | 386, 387 |
464. | Poisoning from Solanine, | 387 |
465. | Separation from Animal Tissues, | 387 |
5. Cytisine. | ||
466. | The Cytisus laburnum, | 387 |
467. | Reactions of Cytisine, | 388 |
468. | Effects on Animals, | 389 |
469. | Effects on Man—Illustrative Cases, | 389, 390 |
VII. THE ALKALOIDS OF THE VERATRUMS. | ||
470. | The Alkaloids found in the Veratrum Viride and Veratrum Album—Yield per Kilogram, | 390-392 |
471. | Veratrine—Cevadine, | 392 |
472. | Jervine, | 393 |
473. | Pseudo-jervine, | 393 |
474. | Protoveratridine, | 393 |
475. | Rubi-jervine, | 394 |
476. | Veratralbine, | 394 |
477. | Veratroidine, | 394 |
478. | Commercial Veratrine, | 394, 395 |
479. | Pharmaceutical Preparations, | 395 |
480. | Fatal Dose, | 395 |
481. | Effects on Animals—Physiological Action, | 395, 396 |
482. | Effects on Man—Illustrative Cases, | 396 |
483. | Symptoms of Acute and Chronic Poisoning, | 396, 397 |
484. | Post-mortem Signs, | 397 |
485. | Separation of the Veratrum Alkaloids from Organic Matters, | 397 |
VIII. PHYSOSTIGMINE. | ||
486. | The Active Principle of the Calabar Bean, | 397, 398 |
487. | Physostigmine or Eserine—Properties, | 398, 399 |
488. | Tests, | 399 |
489. | Pharmaceutical Preparations, | 399, 400 |
490. | Effects on Animals—On Man—The Liverpool Cases of Poisoning, | 400 |
491. | Physiological Action, | 401 |
492. | Post-mortem Appearances, | 401 |
493. | Separation of Physostigmine, | 401, 402 |
494. | Fatal Dose of Physostigmine, | 402 |
IX. PILOCARPINE. | ||
495. | Alkaloids from the Jaborandi, | 402 |
496. | Pilocarpine, | 402, 403 |
497. | Tests, | 403 |
498. | Effects of Pilocarpine, | 403, 404 |
X. TAXINE. | ||
499. | Properties of Taxine, | 404 |
500. | Poisoning by the Common Yew, | 404 |
501. | Effects on Animals—Physiological Action, | 404 |
502. | Effects on Man, | 404, 405 |
503. | Post-mortem Appearances, | 405 |
XI. CURARINE. | ||
504. | Commercial Curarine—Properties, | 405-407 |
505. | Physiological Effects, | 407 |
506. | Separation of Curarine, | 407, 408 |
XII. COLCHICINE. | ||
507. | Contents of Colchicine in Colchicum Seeds, | 408, 409 |
508. | Colchicine—Method of Extraction—Properties, | 409 |
509. | Tests, | 409, 410 |
510. | Pharmaceutical Preparations, | 410 |
511. | Fatal Dose, | 410, 411 |
512. | Effects of Colchicine on Animals, | 411 |
513. | Effects of Colchicum on Man—Illustrative Cases, | 411, 412 |
514. | Symptoms Produced by Colchicum—Post-mortem Appearances, | 412, 413 |
515. | Separation of Colchicine from Organic Matters, | 413 |
XIII. MUSCARINE AND THE ACTIVE PRINCIPLES OF CERTAIN FUNGI. | ||
516. | Description of the Amanita Muscaria—Use of it by the Natives of Kamschatka, | 413, 414 |
517. | Cases of Poisoning by the Fungus itself, | 414, 415 |
518. | Muscarine—Its Properties and Effects, | 415, 416 |
519. | Antagonistic Action of Atropine and Muscarine, | 416 |
520. | Detection of Muscarine, | 416, 417 |
521. | The Agaricus Phalloides—Phallin, | 417 |
522. | Post-mortem Appearances, | 417, 418 |
523. | The Agaricus Pantherinus—The Agaricus Ruber—Ruberine—Agarythrine, | 418 |
524. | The Boletus Satanus, or Luridus, | 418 |
525. | Occasional Effects of the Common Morelle, | 418 |
Division II.—Glucosides. | ||
I. DIGITALIS GROUP. | ||
526. | Description of the Digitalis Purpurea, or Foxglove, | 419 |
527. | Active Principles of the Foxglove—The Digitalins, | 419 |
528. | Digitalein, | 420 |
529. | Digitonin—Digitogenin, | 420 |
530. | Digitalin, | 420 |
531. | Digitaletin, | 420 |
532. | Digitoxin—Toxiresin, | 420, 421 |
533. | Digitaleretin—Paradigitaletin, | 421 |
534. | Other Active Principles in Digitalis; such as Digitin, Digitalacrin, Digitalein, &c., | 421, 422 |
535. | Reactions of the Digitalins, | 422 |
536. | Pharmaceutical Preparations of Digitalin, | 422 |
537. | Fatal Dose, | 422-424 |
538. | Statistics of Poisoning by Digitalis, | 424 |
539. | Effects on Man—Illustrative Cases, | 424-427 |
540. | Physiological Action of the Digitalins, | 427 |
541. | Local Action of the Digitalins, | 427, 428 |
542. | Action on the Heart and Circulation, | 428, 429 |
543. | Action of the Digitalins on the Muco-Intestinal Tract and other Organs, | 429 |
544. | Action of Digitalin on the Common Blow-Fly, | 429 |
545. | Action of the Digitalins on the Frog’s Heart, | 429, 430 |
546. | Post-mortem Appearances, | 430 |
547. | Separation of the Digitalins from Animal Tissues, &c.—Tests, Chemical and Physiological, | 431 |
II. OTHER POISONOUS GLUCOSIDES ACTING ON THE HEART. | ||
1. Crystallisable Glucosides. | ||
548. | Antiarin—Chemical Properties, | 432 |
549. | Effects of Antiarin, | 432 |
550. | Separation of Antiarin, | 432 |
551. | The Active Principles of the Hellebores—Helleborin—Helleborein—Helleboretin, | 433 |
552. | Symptoms of Poisoning by Hellebore, | 433 |
553. | Euonymin, | 433 |
554. | Thevetin, | 434 |
2. Substances partly Crystallisable, but which are not Glucosides. | ||
555. | Strophantin, | 434 |
556. | Apocynin, | 434 |
3. Non-Crystallisable Glucosides almost Insoluble in Water. | ||
557. | Scillain, or Scillitin—Adonidin, | 434 |
558. | Oleandrin, | 435 |
559. | Neriin, or Oleander Digitalin, | 435 |
560. | Symptoms of Poisoning by Oleander, | 435, 436 |
561. | The Madagascar Ordeal Poison, | 436 |
4. Substances which, with other Toxic Effects, behave like the Digitalins. | ||
562. | Erythrophlein, | 436 |
III. SAPONIN—SAPONIN SUBSTANCES. | ||
563. | The Varieties of Saponins, | 436, 437 |
564. | Properties of Saponin, | 437 |
565. | Effects of Saponin, | 437, 438 |
566. | Action on Man, | 438 |
567. | Separation of Saponin, | 438, 439 |
568. | Identification of Saponin, | 439 |
Division III.—Certain Poisonous Anhydrides of Organic Acids. | ||
I. SANTONIN. | ||
569. | Properties of Santonin, | 439, 440 |
570. | Poisoning by Santonin, | 440 |
571. | Fatal Dose, | 440 |
572. | Effects on Animals, | 440 |
573. | Effects on Man—Yellow Vision, | 440, 441 |
574. | Post-mortem Appearances, | 441 |
575. | Separation from the Contents of the Stomach, | 441, 442 |
II. MEZEREON. | ||
576. | Cases of Poisoning by the Mezereon, | 442 |
Division IV.—Various Vegetable Poisonous Principles—not Admitting of Classification Under the Previous Three Divisions. | ||
I. ERGOT OF RYE. | ||
577. | Description of the Ergot Fungus, | 442, 443 |
578. | Chemical Constituents of Ergot—Ergotinine—Ecboline—Scleromucin—Sclerotic Acid—Sclererythrin—Scleroidin—Sclerocrystallin—Sphacelic Acid—Cornutin, | 443-445 |
579. | Detection of Ergot in Flour, | 445 |
580. | Pharmaceutical Preparations, | 445 |
581. | Dose, | 446 |
582. | Ergotism—Historical Notice of Various Outbreaks, | 446, 447 |
583. | Convulsive Form of Ergotism, | 447 |
584. | Gangrenous Form of Ergotism—The Wattisham Cases, | 447, 448 |
585. | Symptoms of Acute Poisoning by Ergot, | 448 |
586. | Physiological Action, as shown by Experiments on Animals, | 448-450 |
587. | Separation of the Active Principles of Ergot, | 450 |
II. PICROTOXIN, THE ACTIVE PRINCIPLE OF THE COCCULUS INDICUS. | ||
588. | Enumeration of the Active Principles contained in the Menispermum Cocculus, | 451 |
589. | Picrotoxin; its Chemical Reactions and Properties, | 451, 452 |
590. | Fatal Dose, | 452 |
591. | Effects on Animals, | 452, 453 |
592. | Effects on Man, | 453 |
593. | Physiological Action, | 453 |
594. | Separation from Organic Matters, | 453, 454 |
III. THE POISON OF ILLICIUM RELIGIOSUM. | ||
595. | Dr. Langaard’s Researches, | 454 |
IV. PICRIC ACID AND PICRATES. | ||
596. | Properties of Picric Acid, | 454 |
597. | Effects of Picric Acid, | 454, 455 |
598. | Tests, | 455 |
V. CICUTOXIN. | ||
599. | Description of the Cicuta Virosa, | 456 |
600. | Effects on Animals, | 456 |
601. | Effects on Man, | 456, 457 |
602. | Separation of Cicutoxin from the Body, | 457 |
VI. ÆTHUSA CYNAPIUM (FOOL’S PARSLEY). | ||
603. | Dr. Harley’s Experiments, | 457 |
VII. ŒNANTHE CROCATA. | ||
604. | The Water Hemlock—Description of the Plant—Cases of Poisoning, | 457, 458 |
605. | Effects of the Water Hemlock, as shown by the Plymouth Cases, | 458 |
606. | Post-mortem Appearances, | 459 |
VIII. OIL OF SAVIN. | ||
607. | Effects and Properties of Savin Oil, | 459 |
608. | Post-mortem Appearances, | 460 |
609. | Separation and Identification, | 460 |
IX. CROTON OIL. | ||
610. | Chemical Properties of Croton Oil, | 461 |
611. | Dose—Effects—Illustrative Cases, | 461 |
612. | Post-mortem Appearances, | 461 |
613. | Chemical Analysis, | 462 |
X. THE TOXALBUMINS OF CASTOR OIL SEEDS AND ABRUS. | ||
614. | The Toxalbumin of Castor Oil Seeds, | 462 |
615. | Toxalbumin of Abrus, | 462, 463 |
XI. ICTROGEN. | ||
616. | Ictrogen, | 463 |
XII. COTTON SEEDS. | ||
617. | Cotton Seeds as a Poison, | 464 |
XIII. LATHYRUS SATIVUS. | ||
618. | Poisonous Qualities of Vetchlings, | 464, 465 |
XIV. ARUM—LOCUST-TREE—BRYONY—MALE FERN. | ||
619. | Arum Maculatum, | 465 |
620. | The Black Bryony, | 465 |
621. | The Locust Tree, | 465 |
622. | Male Fern, | 465, 466 |
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PART VII.—POISONS DERIVED FROM LIVING OR DEAD ANIMAL SUBSTANCES. | ||
Division I.—Poisons Secreted by Living Animals. | ||
I. POISONOUS AMPHIBIA. | ||
623. | Poisonous Properties of the Skin of the Salamandra Maculosa—Salamandrine, &c., | 467 |
624. | Poison from the Toad, | 468 |
II. THE POISON OF THE SCORPION. | ||
625. | Various Species of Scorpions—Effects of the Scorpion Poison, | 468 |
III. POISONOUS FISH. | ||
626. | Poisonous Fish—Illustrative Cases, | 468-470 |
IV. POISONOUS SPIDERS AND INSECTS. | ||
627. | The Bite of the Tarantula—The Bite of the Latrodectus Malmignatus, | 470 |
628. | Effects of the Bite of the Katipo, | 471 |
629. | Ants, &c., | 471 |
630. | The Poison of Wasps, Bees, and Hornets, | 471 |
631. | Cantharides, | 471 |
632. | Cantharidin, | 471, 472 |
633. | Pharmaceutical Preparations of Cantharides, | 472 |
634. | Fatal Dose, | 472 |
635. | Effects on Animals—Radecki’s Experiments—Effects on Man—Heinrich’s Auto-Experiments, | 472, 473 |
636. | General Symptoms Produced by Cantharides, | 473, 474 |
637. | Post-mortem Appearances, | 474 |
638. | Tests for Cantharidin—Distribution in the Body—Dragendorff’s Process, | 475-477 |
V. SNAKE POISON. | ||
639. | Classes of Poisonous Snakes, | 477 |
640. | The Poison of the Cobra, | 478 |
641. | Fatal Dose of Cobra Poison, | 479 |
642. | Effects on Animals, | 479 |
643. | Effects on Man, | 479, 480 |
644. | Antidotes and Treatment—Halford’s Treatment by Ammonia—Permanganate of Potash, | 480, 481 |
645. | Detection of the Cobra Venom, | 482 |
646. | Effects of the Bite of the Duboia Russellii, or Russell’s Viper, | 483 |
647. | The Poison of the Common Viper—The Venom of Naja Haje (Cleopatra’s Asp), | 483, 484 |
Division II.—Ptomaines—Toxines. | ||
648. | Definition of a Ptomaine, | 485 |
Isolation of Ptomaines. | ||
649. | Gautier’s Process, | 485 |
650. | Brieger’s Process, | 485-487 |
651. | Benzoyl Chloride Method, | 487, 488 |
652. | The Amines, | 488-490 |
653. | Methylamine, | 491 |
654. | Dimethylamine, | 491 |
655. | Trimethylamine, | 491 |
656. | Ethylamine, | 491 |
657. | Diethylamine, | 491 |
658. | Triethylamine, | 491 |
659. | Propylamine, | 491 |
660. | Isoamylamine, | 492 |
Diamines. | ||
661. | Rate of Formation of Diamines, | 492 |
662. | Ethylidenediamine, | 492 |
663. | Neuridine, | 493, 494 |
664. | Cadaverine, | 494-496 |
665. | Putrescine, | 496 |
666. | Metaphenylenediamine, | 497 |
667. | Paraphenylenediamine, | 497 |
668. | Hexamethylenediamine, | 497 |
669. | Diethylenediamine, | 497, 498 |
670. | Mydaleine, | 498 |
671. | Guanidine, | 498, 499 |
672. | Methylguanidine, | 499, 500 |
673. | Saprine, | 500 |
674. | The Choline Group, | 500, 501 |
675. | Neurine, | 501 |
676. | Betaine, | 501, 502 |
677. | Peptotoxine, | 502 |
678. | Pyridine-like Alkaloid from the Cuttle-fish, | 502, 503 |
679. | Poisons connected with Tetanus—Tetanine, | 503 |
680. | Tetanotoxine, | 503, 504 |
681. | Mydatoxine, | 504 |
682. | Mytilotoxine, | 505 |
683. | Tyrotoxicon, | 504, 505 |
684. | Toxines connected with Hog Cholera, | 505, 506 |
685. | Other Ptomaines, | 506 |
Division III.—Food Poisoning. | ||
686. | The Welbeck—The Oldham—The Bishop Stortford—The Wolverhampton—The Carlisle, and other Mass Poisonings by changed Food—Statistics of Deaths from Unwholesome Food, | 506-508 |
687. | German Sausage Poisoning, | 509 |
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PART VIII.—THE OXALIC ACID GROUP OF POISONS. | ||
688. | Distribution of Oxalic Acid in the Animal and Vegetable Kingdoms, | 510 |
689. | Properties and Reactions of Oxalic Acid, | 510, 511 |
690. | Oxalate of Lime; its Properties, | 511, 512 |
691. | Use of Oxalic Acid in the Arts, | 512 |
692. | Properties of Hydropotassic Oxalate (Binoxalate of Potash), | 512 |
693. | Statistics of Oxalic Acid Poisoning, | 512 |
694. | Fatal Dose of Oxalic Acid, | 513 |