Alagille Syndrome

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1 The Alagille Syndrome: Overview and Introduction

David Piccoli

2 Bile Duct Development and the Notch Signaling Pathway

Stacey S. Huppert, Kathleen M. Campbell

3 Genetics of Alagille Syndrome

Melissa A. Gilbert, Nancy B. Spinner

4 Liver Disease in Alagille Syndrome

Alyssa Kriegermeier, Andrew Wehrman, Binita M. Kamath, Kathleen M. Loomes

5 Transplant Considerations in Alagille Syndrome

Evelyn Hsu, Elizabeth Rand

6 Cardiac, Aortic, and Pulmonary Vascular Involvement in Alagille Syndrome

Justin T. Tretter, Doff B. McElhinney

7 Vascular Manifestations in Alagille Syndrome

Shannon M. Vandriel, Rebecca N. Ichord, Binita M. Kamath

8 The Renal Sequelae of Alagille Syndrome as a Product of Altered Notch Signaling During Kidney Development

René Romero

9 Skeletal Involvement in Alagille Syndrome

Yadav Wagley, Troy Mitchell, Jason Ashley, Kathleen M. Loomes, Kurt Hankenson

10 Immune Dysregulation in Alagille Syndrome: A Feature of the Evolving Phenotype

Alastair Baker

11 Health-Related Quality of Life and Neurocognition in Alagille Syndrome

Saeed Mohammad, Estella M Alonso

12 Future Therapeutic Approaches for Alagille Syndrome

Emma R. Andersson

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